Dr Wong Pei Shieen | Singapore General Hospital

Dr Wong Pei Shieen
Senior Principal Clinical Pharmacist
Department of Pharmacy
Singapore General Hospital

Dr Wong Pei Shieen is a Senior Principal Clinical Pharmacist in Singapore General Hospital. She is also a lecturer with the Pharmacy Department at National University of Singapore. She works collaboratively with the neurologists, nurses and allied health professionals to optimize pharmacotherapy in neurological conditions. She currently serves as the pharmacy lead for the pharmacogenomics implementation programme and focuses on advancing the integration of pharmacogenomics in clinical care through stakeholders engagement, building clinical decision support tools and education.

Session:

Symposium 4
Precision Medicine: Incorporating Genetics into Clinical Practise
17 April 2026, 1330 - 1500hrs, Room L1-S3, Academia

Presenting Title:

Implementing Clinical Pharmacogenomics in a Large Academic Health System: Early Experience from SingHealth
Pharmacogenomics (PGx) enables the personalization of drug therapy based on an individual’s genetic profile and has the potential to improve treatment efficacy while reducing adverse drug reactions. Despite increasing evidence supporting actionable gene–drug interactions, the clinical application of pharmacogenomics remains limited in many healthcare systems.

SingHealth, the largest public healthcare cluster in Singapore, has embarked on the implementation journey to support the integration of pharmacogenomics into clinical practices. This initiative focuses on establishing institutional governance, prioritizing clinically actionable gene–drug pairs based on international guidelines with a focus on local population data, integrating genomic results into the electronic health record, and developing clinical decision support tools to assist prescribing clinicians.

This presentation will describe the framework used for pharmacogenomics implementation within SingHealth and highlight key operational considerations. We will also discuss on our experience and practical challenges encountered and how close collaboration among clinicians, pharmacists, clinical laboratories, and health informatics teams helps to address the barriers.

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