Dr Jenny Hsieh Yi Chen | Singapore General Hospital

Dr Jenny Hsieh Yi Chen
Consultant
Department of Internal Medicine
Singapore General Hospital

Dr Jenny Hsieh is a Consultant in the Department of Internal Medicine at Singapore General Hospital. Her clinical and academic interests focus on clinical genetics and genomic medicine, particularly the integration of genomic information into adult medicine. She established the adult genetic service at Singapore General Hospital and currently serves as the clinical lead for the pharmacogenomics implementation program within SingHealth. Her work focuses on advancing the use of genomic medicine in clinical care and developing precision medicine initiatives.

Session:

Symposium 4
Precision Medicine: Incorporating Genetics into Clinical Practise
17 April 2026, 1330 - 1500hrs, Room L1-S3, Academia

Presenting Title:

Implementing Clinical Pharmacogenomics in a Large Academic Health System: Early Experience from SingHealth
Pharmacogenomics (PGx) enables the personalization of drug therapy based on an individual’s genetic profile and has the potential to improve treatment efficacy while reducing adverse drug reactions. Despite increasing evidence supporting actionable gene–drug interactions, the clinical application of pharmacogenomics remains limited in many healthcare systems.

SingHealth, the largest public healthcare cluster in Singapore, has embarked on the implementation journey to support the integration of pharmacogenomics into clinical practices. This initiative focuses on establishing institutional governance, prioritizing clinically actionable gene–drug pairs based on international guidelines with a focus on local population data, integrating genomic results into the electronic health record, and developing clinical decision support tools to assist prescribing clinicians.

This presentation will describe the framework used for pharmacogenomics implementation within SingHealth and highlight key operational considerations. We will also discuss on our experience and practical challenges encountered and how close collaboration among clinicians, pharmacists, clinical laboratories, and health informatics teams helps to address the barriers.

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