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Nuclear Medicine & PET Overview
Our centre is one of the region's largest Nuclear Medicine departments and provides a comprehensive range of clinical services in radioisotope imaging and therapy. We are equipped with a Positron Emission Tomography (PET)/CT scanner with Time-of-Flight technology, two Single Photon Emission Computed Tomography (SPECT)/CT scanners and three gamma cameras. We also have seven inpatient beds and three outpatient clinic rooms for therapy consultations.
The following are some of our subspecialties:
Nuclear Medicine Therapy
Radioiodine therapy is the oral administration of radioactive iodine (iodine-131) for the treatment of thyrotoxicosis (e.g. Graves’ disease, toxic multinodular goiter or toxic adenoma) and differentiated thyroid carcinomas.
Selective internal radiation therapy (SIRT)
Selective internal radiation therapy (SIRT) is a form of local radiation therapy for unresectable liver tumours. The procedure is performed in close coordination with interventional radiologists by delivering radioactive Yttrium-90 microspheres into the arteries supplying the tumours.
Peptide receptor radionuclide therapy (PRRT)
Peptide receptor radionuclide therapy (PRRT) is a molecular targeted therapy for inoperable metastatic well- or moderately-differentiated neuroendocrine tumours. It can also be used for other tumours with high somatostatin receptors expression. The treatment is performed with intravenous administration of radioactive somatostatin analogue (e.g. Lutetium-177 or Yttrium-90-labeled radiopeptide).
Iodine-131 MIBG therapy
Iodine-131 MIBG therapy is a systemically administered radiotherapy used in the treatment of inoperable metastatic neuroectodermal tumours such as pheochromocytoma, paraganglioma, neuroblastoma, medullary thyroid cancer and carcinoid tumors.
Radiosynovectomy is a radionuclide therapy to treat chronic joint synovitis or synovial processes. The majority of our referrals are of chronic inflammatory arthritis e.g. rheumatoid arthritis, and haemophilic synovitis. The treatment is performed by intra-articular injection of the colloidal form of Yttrium-90, Rhenium-186 and Erbium-169.
Bone pain palliative therapy
Bone-seeking radiopharmaceuticals (e.g. Strontium-89 chloride, Samarium-153, Rhenium-188) are used for the palliation of pain from bone metastases.
Radio-labelled (e.g. Yttrium-90, Iodine-131) anti-CD20 monoclonal antibody therapy for refractory/relapsed low-grade non-Hodgkin's lymphoma
Nuclear Medicine Imaging
Positron Emission Tomography (PET)
Advanced imaging technique for oncology, cardiology and neurology. State-of-the-art fusion PET/CT scanner provides functional information with anatomic correlation. Current radiotracers include:-
- Fluorine-18 FDG for tumour and infection imaging, to assess myocardial viability and for the work-up of early dementia and refractory epilepsy
- Gallium-68 DOTATATE and analogues for neuroendocrine and other somatostatin receptor positive tumours
- Fluorine-18 Choline for brain and prostate tumours
Routine Nuclear Medicine Scan
- Bone scintigraphy for assessment of bone metastases and other skeletal abnormalities. Bone mineral densitometry - for assessment of bone mass and evaluation of osteopenia and osteoporosis.
- Nuclear cardiology with myocardial perfusion imaging and radionuclide gated-ventriculography.
- Brain perfusion imaging for cerebrovascular insufficiency, epilepsy and brain death.
- Renal imaging including renography, captopril studies and renal cortical imaging.
- Thyroid scintigraphy for assessment of thyroid nodules and thyroid function.
- Parathyroid scintigraphy for localisation of parathyroid adenomas in hyperparathyroidism.
- Gastrointestinal studies e.g. radionuclide tagged-red blood cells scan, Meckel's scan, hepatobiliary scan, gastric emptying study and peritoneal scan.
- Lung studies including V/Q scan for pulmonary embolism and lung perfusion scan for lung function quantification prior to surgery.
- Iodine-131 MIBG and Indium-111octreotide imaging for neuroendocrine tumours.
- Lymphoscintigraphy for lymphoedema.
- Sentinel node scintigraphy and radionuclide occult lesion localisation (ROLL) for breast cancers.
- Labelled white-blood cells scan for infection localisation.
Non-Imaging Nuclear Medicine Tests
- Chromium-51 EDTA renal clearance study for evaluation of glomerular filtration rate
- Helicobacter pylori C-14 breath test (Urea Breath Test)
- Hormone assays for assessing thyroid, fertility and metabolic functions (available from our Endocrine Laboratories).
|Head and Senior Consultant|
|Dr Ng Chee Eng David MBBS, MRCP (UK), FAMS||Nuclear Medicine and PET|
|Senior Consultant, Director, Endocrine Laboratories|
|Dr Aw Swee Eng MBBS, PhD (Chem Path)(Lond), FRCPath (Lond), FAMS||Clinical Biochemistry, Endocrinology|
|Dr Goh Soon Whatt, Anthony MBBS (Spore), MSc (Nucl Med) UK, FAMS||Nuclear Medicine and PET|
|Dr Wong Wai Yin MBBS, FRCR (UK), FAMS||Nuclear Medicine and PET|
|Dr Lam Wing Chuen, Winnie MBBS, FRCR (UK), FAMS||Nuclear Medicine and PET|
|Dr Loke Siu Hoong Kelvin MBBS, FAMS, MRCP (UK)||Nuclear Medicine and PET|
|Dr Sumbul Zaheer MBBS (Aligarh), MRCP (UK)||Nuclear Medicine and PET|
|Dr Yan Xuexian MD, ABNM||Nuclear Medicine and PET|
|Dr Thang Sue Ping MBChB (Edinburgh), MRCP(UK)||Nuclear Medicine & PET|
|Dr Xie WanYing MBBS, FRCR, MMed||Nuclear Medicine and PET|
|Dr Butch M Magsombol MD (Far Eastern), Dip (Nuclear Med) (AMS)||Nuclear Medicine|
Tel : 6326 5357
(for PET appointment)
Fax: 6326 5449
Tel : 6321 4203 / 6321 3838 (for other appointments)
Fax : 6326 5338
Academia, Level 4
Tel: 6326 6040
Fax: 6224 0938
(for departmental matters only)