Research Urology | Singapore General Hospital

Beyond providing clinical services to cover a wide spectrum of urological conditions, the department also has strong endeavors in research, contributing to the body of knowledge in the field. This comprises of several grant-supported clinical trials as well as research harnessing the strengths of our robust prospectively maintained cancer registry and database.

Current ongoing clinical trials:

Randomised Control Trial to evaluate the effectiveness of Extracorporeal Shockwave Therapy (ESWT) for Patients with High Tone Pelvic Floor Dysfunction
Prostate Cryotherapy: Phase II Trial of Focal Cryotherapy for Prostate Cancer
A Prospective Pilot Study of MRI-TRUS fusion Robotic Guidance for Focal Cryotherapy of Prostate Cancer
Mitochondrial DNA Deletions in Plasma for Detection of Significant Prostate Cancer in men with PSA <10ng/ml undergoing MRI-ultrasound fusion prostate biopsy
PSMAddition: A phase 3 trial to compare treatment with 177Lu-PSMA-617 plus standard of care (SOC) versus SOC alone in patients with metastatic hormone-sensitive prostate cancer
Prevalence of Oxalobacter formigenes in Singapore population and comparison of fecal microbiome between calcium oxalate stone formers and controls　
Development and Validation of Novel Point of Care Urine Biochemistry Device
Tipless Urinary Catheter – Randomised Controlled Clinical Trial evaluating Efficacy and Safety
Wee Care
Effect of Preoperative Prostate Artery Embolisation on Intraoperative Blood Loss During Transurethral Resection for Large Prostate glands >80g

Department publications:

Head-to-head Comparison of the Diagnostic Accuracy of Prostate-specific Membrane Antigen Positron Emission Tomography and Conventional Imaging Modalities for Initial Staging of Intermediate- to High-risk Prostate Cancer: A Systematic Review and Meta-analysis.
European Urology March 2023
https://pubmed.ncbi.nlm.nih.gov/37032189/
Robotic-assisted laparoscopic non-dismembered side-to-side tapered neoureterocystostomy – A technique for maximal ureteric vascular preservation in megaureter patients.
Urology Video Journal March 2023
https://www.sciencedirect.com/science/article/pii/S2590089723000026?via%3Dihub
Patient-reported functional outcomes and oncological control after primary focal cryotherapy for clinically significant prostate cancer: A Phase II mandatory biopsy-monitored study.
The Prostate March 2023
https://pubmed.ncbi.nlm.nih.gov/36895163/
Natural language processing in urology: Automated extraction of clinical information from histopathology reports of uro-oncology procedures
Heliyon March 2023
https://pubmed.ncbi.nlm.nih.gov/37025805/
Development and Validation of a Deep Learning System for Sound-based Prediction of Urinary Flow.
Eur Urol Focus Jan 2023
https://pubmed.ncbi.nlm.nih.gov/35835694/