Synonym(s):
Performing Laboratory: Mayo Clinic Laboratories, Rochester
2 tubes of 3 mL EDTA blood
Draw blood from the patient in a seated position.
Collect blood directly into a chilled EDTA tube and immediately keep cold in ice.
Keep cold with ice and send immediately to the laboratory.
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Mayo Clinic Laboratories Reference Interval:
0 - 2 years: 4.6 ng/mL/hour (mean)* Range: 1.4-7.8 ng/mL/hour3 - 5 years: 2.5 ng/mL/hour (mean)* Range: 1.5-3.5 ng/mL/hour6 - 8 years: 1.4 ng/mL/hour (mean)* Range: 0.8-2.0 ng/mL/hour9 - 11 years: 1.9 ng/mL/hour (mean)* Range: 0.9-2.9 ng/mL/hour12 - 17 years: 1.8 ng/mL/hour (mean)* Range: 1.2-2.4 ng/mL/hourMean data not standardized as to time of day or diet. Infants were supine, children sitting.
*Reference: Stalker HP, Holland NH, Kotchen JM, Kotchen TA: Plasma renin activity in healthy children. J Pediatr 1976;89:256-258 Peripheral vein specimenNa-deplete, upright18 - 39 years: 10.8 ng/mL/hour (mean)2.9 - 24.0 ng/mL/hour (range)
≥ 40 years: 5.9 ng/mL/hour (mean)2.9 - 10.8 ng/mL/hour (range) Na-replete, upright18 - 39 years: 1.9 ng/mL/hour (mean)≤ 0.6 - 4.3 ng/mL/hour (range)
≥ 40 years: 1.0 ng/mL/hour (mean)≤ 0.6 - 3.0 ng/mL/hour (range)
Up to 9 working days
This test is sent out to Mayo Clinic Laboratories for testing.
Mayo Clinic Renin Activity, Plasma
Patient preparation:
The plasma renin activity cannot be interpreted if the patient is treated with spironolactone (Aldactone).
Spironolactone should be discontinued for 4 to 6 weeks before testing.
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