Profile
Asst Prof Thowfique Ibrahim was born in 1968 in a picturesque green valley, Koottickal, Kerala State, India. He attended a Catholic missionary high school, Junior College and graduated from Government Medical School in Kottayam, Kerala state, in 1990 at the age of 22.
The PLAB examination was successfully undertaken in 1996 and started the postgraduate training in Pediatrics in the UK. The workplaces include major university hospitals in the UK, including the Neonatal Unit attached to St Georges Medical School, Tooting, Birmingham Heartland Hospital, and Leeds General Infirmary attached to Leeds University. The MRCP examination was passed in 1999 and became a specialist registrar trainee in pediatrics. The fellowship in Neonatal-Perinatal Medicine at the University of Calgary, Canada, was offered to me in 2001, and the position was accepted in 2002. Upon completing the program, I was certified as a subspecialist in Neonatal-Perinatal Medicine in 2004 and moved to Dubai Hospital, attached to Dubai Medical College. He moved to Singapore in 2007 and have worked at KK Women's and Children's Hospital.
Education
- FRCPCH (UK) 2018
- FAMS (Singpaore) 2013
- MRCPCH (UK) 2011
- Fellowship in Neonatal-Perinatal Medicine (Canada) 2004
- MRCP (Paeds) (UK) 1999
- MBBS (India) 1992
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Professional Appointments and Committee Memberships
- Senior Consultant, Department of Neonatology, KK Women’s and Children’s Hospital (KKH), 2014- till present
- Member, KKH ECMO Committee, 2016-present
- Member, KKH Consent Committee
- Department Committee on JCI Recertification
- POCT Committee, 2018-2019
- Hospital Committee on Serious Reportable Events (SRE) – Member
- Hospital Committee on Transfusion in ECMO patients – Member
- Head of Publication, Perinatal Society of Singapore, 2012-2020
- Committee member, Perinatal Society of Singapore, 2020-2022
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Awards
- National Medical Research Council Clinical Trial Grant Award (2022).
- Healthcare Hero Award, Covid-19, SingHealth, 2021
- Certificate of Excellence Merit (senior category), ACP Program 2021
- Service from the Heart Award 2018 KKH
- Long Service Award 10 years, SingHealth 2018
- Singapore Health Quality Service Awards, Silver 2017
- NUS University Medtech Studio Award 2018 Finalist (Top 8)
- HMDP Award 2011 for the development of the ECMO program in Singapore
- Clinical Special Recognition Award 2013, KKH
- Singapore Health Service Quality Award 2012 - Silver
- Merit Award – Video Presentation on 'Redesign neonatal care to reduce the burden of intraventricular hemorrhage (IVH) in VLBW infants – an accelerated model of improvement (AMI TM) project at 7th KKH ASM 2013
- Best Poster Award - 'Redesign neonatal care to reduce the burden of intraventricular hemorrhage (IVH) in VLBW infants – an accelerated model of improvement (AMI TM) project at SiPPAC 2013
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Research Interests
- Treatment of Meconium obstruction of prematurity, gut microbiome, and Gut-Brain interaction in newborn infants.
- Treatment of patent ductus arteriosus(PDA) in premature infants
- Prevention of brain hemorrhage in premature infants
- ECMO in the Neonatal population
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Publications
- T Ibrahim, CL Wei, D Bautista, B Sriram, LX Fay, VS Rajadurai Saline Enemas versus Glycerin Suppositories to Promote Enteral Feeding in Premature Infants: A Pilot Randomized Controlled Trial. Neonatology. 2017. 112 (4), 347-353
- Kirpalani H, Millar D, Lemyre B, Yoder BA, Chiu A, Roberts RS; NIPPV Study Group. A trial comparing noninvasive ventilation strategies in preterm infants. N Engl J Med. 2013 August 15;369(7):611-20.
- Ibrahim T, Abdul Haium AA, Tapawan SJ, Dela Puerta R, Allen JC Jr, Chandran S, Chua MC, Rajadurai VS Selective Treatment of PDA in High-Risk VLBW Infants With Birth Weight ≤800 g or <27 Weeks and Short-Term Outcome: A Cohort Study. Front Pediatr. 2021 Jan 28;8:607772.
- Kathleen J Lumb, Jennifer M Schneider, Thowfique Ibrahim, Anita Rigaux, Shabih U Hasan. Afferent neural Feedback overrides the modulating effects of arousal, hypercapnia, and hypoxemia on neonatal cardiorespiratory control. J Physiol 201 April 20. Epub 2018 April 20
- Ibrahim T, Abdul Haium AA, Chandran S, Rajadurai VS Current controversies in the management of PDA in preterm infants. Indian Paediatrics 2014 Apr; 51:289-94
- H Kirpalani H, Millar D, LemyreB, Yoder BA, Chiu A, Roberts RS. Nasal intermittent positive pressure (NIPPV) does not confer benefit above nasal CPAP(nCPAP) in extremely low birth weight(ELBW) infants < 1000g BW-The NIPPV International.
- T Ibrahim, L W Chiang, B Sriram, XF Li, DCT Bautista, VS rajadurai. Effect of early aggressive meconium evacuation with normal saline rectal wash out on time to reach full enteral feeds on VLBW infants. A Pilot RCT(Me Vac trial).European Journal of Pediatrics 175(11) 1722-1723.
- IbrahimT, CL Wei, Wimala C, Yusuf MSB, Srinivasan L, Yuen PL, Allen JAC, Rajadurai VS. The Feasibility of twice daily saline enema to treat meconium inspissation in premature infants. A pilot randomized controlled trial. E-PAS 2018 4129.275
- Ibrahim, CL Wei, Wimala C, Yusuf MSB, Srinivasan L, Yuen PL, Allen JAC, Rajadurai VS.Safety and efficacy of nurse-led saline enema administration for the treatment of meconium obstruction of prematurity.E-PAS2021:1665
- Ibrahim T, Tapawan SJC, Haium AAA, Michigan C, Allen J, B Dela Puerta R. Does selective treatment of PDA in high-risk VLBW infants with Birth weight ≤ 800g or < 27 weeks affect the short-term outcome. A cohort study.E-PAS2019:2842.352
- T Ibrahim, CL Wei, D Bautista, B Sriram, LX Fay, VS Rajadurai Saline Enemas versus Glycerin Suppositories to Promote Enteral Feeding in Premature Infants: A Pilot Randomized Controlled Trial. Neonatology 112 (4), 347-353
- Kirpalani H, Millar D, Lemyre B, Yoder BA, Chiu A, Roberts RS; NIPPV Study Group. A trial comparing noninvasive ventilation strategies in preterm infants. N Engl J Med. 2013 August 15;369(7):611-20.
- H Kirpalani H, Millar D, LemyreB, Yoder BA, Chiu A, Roberts RS. Nasal intermittent positive pressure (NIPPV) does not confer benefit above nasal CPAP(nCPAP) in extremely low birth weight(ELBW) infants < 1000g BW-The NIPPV International.
- T Ibrahim, L W Chiang, B Sriram, XF Li, DCT Bautista, VS rajadurai.Effect of early aggressive meconium evacuation with normal saline rectal wash out on time to reach full enteral feeds on VLBW infants. A Pilot RCT(Me Vac trial).European Journal of Pediatrics 175(11) 1722-1723.
- IbrahimT, CL Wei, Wimala C, Yusuf MSB, Srinivasan L, Yuen PL, Allen JAC, Rajadurai VS. The Feasibility of twice daily saline enema to treat meconium inspissation in premature infants. A pilot randomized controlled trial. E-PAS 2018 4129.275
- Ibrahim, CL Wei, Wimala C, Yusuf MSB, Srinivasan L, Yuen PL, Allen JAC, Rajadurai VS.Safety and efficacy of nurse-led saline enema administration for the treatment of meconium obstruction of prematurity.E-PAS2021:1665
- Ibrahim T, Tapawan SJC, Haium AAA, Michigan C, Allen J, B Dela Puerta R. Does selective treatment of PDA in high-risk VLBW infants with Birth weight ≤ 800g or < 27 weeks affect the short-term outcome. A cohort study.E-PAS2019:2842.352
- Ibrahim T, Rajadurai VS, Gomez JM, Sriram B, Sriram S, Wong KY. The outcome of extracorporeal membrane oxygenation for neonatal refractory respiratory failure. Ann Acad Med Singapore 2013 Nov; 42(11):615-7
- Ibrahim T. Agarval A, Tan D, Haium AAA, Sarjono SB, Badillo MC,Kavalloor NV, Sultana R,Rajadurai VS. The outcome of a severe intraventricular hemorrhage prevention bundle in very low birth weight infants. Application of a modified quality improvement methodology. E-PAS2022,231.127
- Tan MX, Hium AAA, Visruthan NK, Rajadurai VS, Ibrahim T. Validity of an IVH and PVL prevention bundle interventions in a centre with a very low incidence of severe IVH: A case-control study.BMJ Paediatrics Open 2021;5(Suppl 1):A1-A132
- Ibrahim Thowfique K, Jauhari Praveen, Phillip Louis, Hilderbrandt T, Stutchfield Peter. Multiple courses of antenatal steroids do not produce adverse neurological outcomes in premature babies at two years. A population-based study. Pediatric Research 2003; 53(4 Part 2):378a, II.
- Ibrahim T, Rajadurai VS, Sriram B, Sriram S, Lim YP, Masakazu N, Wong KY. Neonatal extracorporeal membrane oxygenation programme at KKH: initial experience. Singapore Med J 2011:52(2 Suppl):S90
- Thowfique I, Agarwal P, Bhavani S, Rajadurai VS Clinical risk Index of Babies (CRIB) score and Neonatal Outcome in very low birth weight (VLBW) Infants. Proceedings of Singapore Healthcare, Vol 19, No 2 (Suppl), 2010.
- J H Livingstone. T Ibrahim. Bradycardia without associated hypertension: A common sign of Ventriculoperitoneal shunt malfunction. BPNA annual scientific meeting, New Castle upon Tyne, 2002.
- Ibrahim T, Rajadurai VS, Sriram B, Sriram S, Lim YP, Masakazu N, Wong KY. Neonatal Extracorporeal Membrane Oxygenation Program at KK Hospital Singapore: Initial Experience. Proceedings of Singapore Healthcare, Vol 21, No 1 (Suppl) 2012
- Ibrahim T, Jauhari P, Stanchfield P. Neurological Consequences of Antenatal Steroid. Consensus and Controversies. Wel Paediatr J 2002;12:212-7
- S Vora, T Ibrahim, VS Rajadurai.Indian paediatrics. Maternal pseudo-barter syndrome associated with severe perinatal brain injury. Indian paediatrics 54 (9), 771-773
- Shrenik Vora, Thowfique Ibrahim, Victor Samuel Rajadurai.Radial artery pseudoaneurysm in a neonate with haemophilia A. Indian Pediatr 2014 Nov;51(11):9213
- Singh SA, Ibrahim T, Clark DJ, Taylor RS, George DH. Persistent Pulmonary Hypertension of Newborn due to Congenital Capillary Alveolar Dysplasia. Pediatr pulmonology.2005 Oct;40(4):349-53
- TK Ibrahim, AAA Haium, S chandran. Correspondence. Indian Pediatr 51, 289-294
- Atasay, B., Erdeve, O., singh, Y, salimon, H., eds(2021). Management of patent ductus arteriosus in preterm infants.Lausanne:Frontiers Media SA. Page 160-169.doi:10.3389/978-2-88966-803-8
- Shui Yen, S.Saumya, J.Puthucheary J. Baby Bar Book. Patent Ductus Arteriosus. A Practical Guide On Pediatrics. Third edition. Singapore: Page 393-394.Red Cells Series,C2015
- Ibrahim Thowfique K, Jauhari Praveen, Phillip Louis, Hilderbrandt T, Stutchfield Peter. Multiple courses of antenatal steroids do not produce adverse neurological outcomes in premature babies at two years. A population-based study. Pediatric Research 2003; 53(4 Part 2):378a, II.
- Ibrahim T, Rajadurai VS, Sriram B, Sriram S, Lim YP, Masakazu N, Wong KY. Neonatal extracorporeal membrane oxygenation programme at KKH: initial experience. Singapore Med J 2011:52(2 Suppl):S90
- Thowfique I, Agarwal P, Bhavani S, Rajadurai VS Clinical risk Index of Babies (CRIB) score and Neonatal Outcome in very low birth weight (VLBW) Infants. Proceedings of Singapore Healthcare, Vol 19, No 2 (Suppl), 2010.
- Ibrahim T, Rajadurai VS, Sriram B, Sriram S, Lim YP, Masakazu N, Wong KY. Neonatal Extracorporeal Membrane Oxygenation Program at KK Hospital Singapore: Initial Experience. Proceedings of Singapore Healthcare, Vol 21, No 1 (Suppl) 2012
- H Kirpalani, D Millar, B Lemyre, B Yoder, A Chiu, R Roberts Nasal intermittent positive pressure (NIPPV) does not confer benefit above nasal CPAP (nCPAP) in extremely low birth weight (ELBW) infants< 1000 g BW—The NIPV International.E-PAS2012 1675
- The Feasibility of twice daily saline enema to treat meconium inspissation in premature infants: A pilot randomized controlled trial. Ibrahim Thowfique, Luxna S, Yuen Poh Leng, Wimala Charlene, Rajadurai Victor S. Chiang Li Wei.PAS 2018, Toronto
- Effect of early aggressive meconium evacuation with normal saline rectal washout on time to reach full feeds in VLBW infants. T Ibrahim, LW Chiang, B Sriram, XF Li, DCT Bautista, VS Rajadurai. European Journal of Pediatrics 175 (11), 1722-1723
- Feasibility of an algorithmic approach to manage PDA in VLBW infants. T Ibrahim, K Calinao, S Tapawan, R Dela Puerta, A Alim, Chua MC, VS Rajadurai
KK Women’s and Children’s Hospital, Singapore. EPNCIC 2017, Marbella, Spain
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Research Trials
- Saline enema and treatment of meconium inspissation of prematurity. Impact on establishing enteral feeds, gut microbiome, inflammation, immunity and developing brain in extremely low birth weight infants. (National Medical Council funded current project)
- Nasal Intermittent Positive Pressure Ventilation in Preterm Infants (NIPPV) Trial (Published)
- The effect of early aggressive meconium evacuation on duration to reach full oral feeds in VLBW infants: a randomized control trial comparing regular daily saline rectal washout with conventional management using glycerin suppositories (Published)
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