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Assoc Prof Ong Chin-Ann Johnny

Assoc Prof Ong Chin-Ann Johnny

MBBS (S'pore), MRCS (Ed), M Med (Surgery), FRCS (Ed), PhD (Cambridge)

Senior Consultant

National Cancer Centre Singapore

Specialty: Surgery & Surgical Oncology, Sarcoma, Peritoneal and Rare Tumours (SPRinT)

Sub-specialties: Peritoneal-based Malignancies, Sarcoma, Skin & Melanoma, Colorectal, Gastrointestinal, Gastrointestinal Oncology, General Surgery, Gynae-Oncology, Lymphoma (DMO, DRO), Melanoma, Pelvic & Peritoneal, Sarcoma/Skin, Supportive & Palliative Care, Upper Gastrointestinal

Conditions Treated by this Doctor:
Anal Cancers, Colorectal Cancer, Gastrointestinal Stromal Tumour (GIST), Lymphoma, Melanoma, Ovarian Cancer, Peritoneal based Malignancies, Sarcoma, Skin Cancer, Stomach Cancer.

Clinical Appointments

  • Senior Consultant Division of Surgery & Surgical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore
  • Senior Consultant Sarcoma, Peritoneal and Rare Tumours (SPRinT) Singapore General HospitalSingapore General Hospital
  • Visiting Consultant KK Women's and Children's HospitalKK Women's and Children's Hospital

Academic Appointments

  • Clinical Tutor, Yong Loo Lin School of Medicine
  • Adjunct Teaching Faculty member, Lee Kong Chian School of Medicine
  • Principal Investigator, Laboratory of Applied Human Genetics, National Cancer Centre Singapore
  • Clinical Core Faculty Member (CCFM), SingHealth Surgery Residency Programme
  • Associate Professor, Duke-NUS Graduate Medical School

Profile

Dr Johnny Ong is a Senior Consultant in the Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore. He is also the Principal Investigator of the Laboratory of Applied Human Genetics, NCCS.

Dr Ong is currently one of the only formally trained surgeons for sarcoma in Singapore. He was awarded the Health Manpower Development Plan (HMDP) Fellowship in 2018 to train at one of the largest soft tissue sarcoma units in Europe at the Royal Marsden Hospital, UK. Dr Ong also underwent a clinical observership at the renowned Sarcoma Unit in the Instituto Nazionale Tumori, Milan. He is one of the key opinion leaders in the field of sarcoma and seeks to advance the care of sarcoma in Singapore and Asia Pacific. Dr Ong was also trained in the advanced management of melanomas at the Royal Marsden Hospital, UK. Additionally, he has worked extensively in the Surgical Oncology unit in SGH/NCCS in the treatment for peritoneal disease. He is an EXCO member of the Asian Peritoneal Surface Malignancy Group (APSMG), an international consortium of regional medical centres which aims to increase awareness and improve standards of management for peritoneal malignancies in Asia.

Dr Ong graduated from Yong Loo Lin School of Medicine in 2004 and obtained his MRCS (Edin) in 2008 and FRCS (Edin) in 2016. He had won multiple awards since his medical school years, including Dean's List and Best Registrar Award. Spurred on by his interest in scientific research, Dr Ong pursued a PhD in the Department of Oncology at the University of Cambridge, UK, from 2009 to 2013, which was funded by the NRF-MOH research scholarship.

Dr Ong is the Principal Investigator of the Laboratory of Applied Human Genetics in NCCS which aims to uncover novel therapeutics for the treatment of peritoneal disease. His PhD experience in Cambridge coupled with his clinical background have provided him a firm understanding of the pathogenesis of peritoneal disease. Dr Ong was awarded the NMRC Transition Award in 2017 and NMRC Clinician Scientist-Individual Research Grant in 2021 and continues to strive towards his goal as a surgeon-scientist, setting his sights on battling peritoneal disease by identifying novel mutations and biomarkers that could serve as diagnostic or prognostic markers of disease as well as to identify novel therapeutic strategies.

Apart from his clinical and research involvement, Dr Ong is passionate about medical education and mentoring medical students, junior doctors, and young aspiring clinician-scientists. Since 2013, Dr Ong  has assisted with the training of regional doctors to improve health care in South-East Asia on endoscopy, clinical algorithm and surgery. He is a clinical tutor in all three medical schools in Singapore and is also an examiner in the Final Professional MBBS Examinations in Yong Loo Lin School of Medicine. Additionally, Dr Ong has served as a mentor and co-mentor to numerous Duke-NUS students for their 3rd Yearly Scholarly Development Programme. He is an inspiration to many young aspiring doctors as evident by the multiple Teaching and Special Recognition Awards received. His students speak fondly of his passion in nurturing the next generation, ensuring that the upcoming doctors are competent and always maintaining the patients as their first priority. Dr Ong is happy to receive any queries from students and medical doctors who are interested in clinical attachments or joining the laboratory at any time.

Education

  • Royal College of Surgeons (Edinburgh), FRCS, 2016
  • National University of Singapore (Yong Loo Lin School of Medicine), Master of Medicine, 2016
  • University of Cambridge (Oncology), PhD, 2013
  • Royal College of Surgeons (Edinburgh), MRCS, 2008
  • National University of Singapore (Yong Loo Lin School of Medicine), MBBS, 2004

Professional Appointments and Committee Memberships

  • Member, FY2022 SingHealth Foundation Talent Development Fund (TDF) & Ministry of Health In-Service Scholarship (MOH-ISS) Research Interview Panel
  • Member, Undergraduate Curriculum Committee, Division of Surgery and Surgical Oncology (01/04/2021 – 31/03/2023)
  • Clinical Core Faculty Member (CCFM), SingHealth Surgery Residency Programme (01/07/2020 – 30/07/2023)
  • Joint Research Clinician, Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entites (2020 – 2023)
  • Member, SurgeryACP Research Strategic Workgroup (2020 – Present)
  • Member, Grant Monitoring Panel for NCCS Cancer Fund (Research) (2020 – Present)
  • Programme Director, Surgical Oncology Fellowship Programme, Division of Surgery and Surgical Oncology, NCCS (2019 – Present)
  • Adjunct Teaching Faculty Member, Lee Kong Chian School of Medicine, NTU (2019 – 2023)
  • Head of Research, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, NCCS (2019 – Present)
  • Consultant, Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, NCCS (2019 – Present)
  • Research Mentor, Duke-NUS Medical School (2018 – Present)
  • Assistant Professor, Duke-NUS Medical School (2017 – Present)
  • Principal Investigator, Laboratory of Applied Human Genetics, Division of Medical Sciences, NCCS (2014 – Present)

Awards

  • NMRC Clinician Scientist-Individual Research Grant, NMRC, 2021
  • Special Recognition Award, Yong Loo Lin School of Medicine, NUS, 2021
  • Outstanding Faculty Award, SingHealth Residency, 2021
  • Special Recognition Award, Yong Loo Lin School of Medicine, NUS, 2020
  • Outstanding Faculty Award, SingHealth Residency, 2020
  • Silver Award, SingHealth Quality Service Awards, 2020
  • Special Recognition Award, Yong Loo Lin School of Medicine, NUS, 2019
  • Health Manpower Development Plan (HMDP) Fellowship, Ministry of Health, 2019
  • Special Recognition Award, Yong Loo Lin School of Medicine, NUS, 2018
  • Khoo Pilot Award (Collaborative), Duke-NUS Medical School, 2018
  • NMRC Transition Award, NMRC, 2017
  • Special Recognition Award, Yong Loo Lin School of Medicine, NUS, 2017
  • Dean's Excellence Award, Yong Loo Lin School of Medicine, NUS, 2017
  • Distinguished Young Researcher Award, SingHealth Excellence Awards, 2016
  • 1st Prize, Young Investigator's Award (Basic/Translational Research), SGH Annual Scientific Meeting 2015, 2015
  • Best Registrar Award, SingHealth, 2015
  • Best Poster prize, British Society of Gastroenterology (Cambridge), 2013
  • Overseas travel grant, United European Gastroenterology Week (UEGW) (Amsterdam), 2012
  • Best Poster prize, Hutchison-MRC Annual Retreat (Cambridge), 2011
  • 3rd prize for oral presentation, 4th National Barrett's Symposium (London), 2010
  • NRF-MOH Overseas Scholarship, Ministry of Health, 2008
  • SingHealth Service with a Heart Award, SingHealth, 2008
  • Best Physical Training Award, Singapore Armed Forces, 2006
  • Dean's List, Yong Loo Lin School of Medicine, 2003
  • Best Trainee, School of Infantry Specialists, 1999

Research Interests

  • Cancer metastasis
  • Tumour microenvironment
  • Biomarkers
  • Novel therapeutic strategies

Publications

  • Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population
Lim HJ*, Ong C-AJ*, Skanthakumar T, Mak LYH, Wasudevan SD, Tan JWS, Chia CS, Tan GHC, Teo MCC

    Health Qual Life Out 2020 (Accepted for publication)
    
JIF: 2.318 , times cited: NA (* Equal contribution)
  • Exosome-templated nanoplasmonics for multiparametric molecular profiling Wu X, Zhao H, Natalia A, Lim CZJ, Ho NRY, Ong C-AJ, Teo MCC, So JBY, Shao HL.
    Science Advances Biophysics 2020
    Top 20% journal, JIF: 11.5, times cited: NA
  • Management of Synchronous Lateral Pelvic Nodal Metastasis in Rectal Cancer in the era of Neoadjuvant Chemoradiation: A Systemic Review
Wong JSM, Tan GHC, Chia CS, Ong C-AJ, Teo MCC

    World J Gastrointest Surg 2020
    JIF: NA, times cited: NA
  • Axillary Lymph Node Dissection in Angiosarcomas of the Breast: An Asian Institutional Perspective.
Ragavan S*, Lim HJ*, Tan JWS, Hendrikson J, Chan JY, Farid M, Chia CS, Tan GHC, Soo KC, Teo MCC, Ong C-AJ**
    Sarcoma 2020
    JIF: NA, times cited: 1
(* Equal contribution, ** Corresponding author)
  • Novel prognostic score for outcomes after cytoreductive surgery and HIPEC for colorectal cancer with metachronous peritoneal carcinomatosis.
Chin KM, Tan GHC, Chia CS, Ong CAJ, Teo M

    ANZ Journal of Surgery 2020

    JIF: 1.605, times cited: NA
  • Primary iliocaval leiomyosarcomas: The path beyond surgery.
Ong CAJ, Smith MJ, Snow HA, et al.

    Eur J Surg Oncol 2020

    JIF: 3.379, times cited: 1
  • An optimised protocol harnessing laser capture microdissection for transcriptomic analysis on matched primary and metastatic colorectal tumours.
Ong CAJ*, Tan QX*, Lim HJ*, Shannon NB, et al.

    Scientific Reports 2020
    
JIF: 4.609 , times cited: NA (* Equal contribution)
  • The importance of synchronicity in the management of colorectal peritoneal metastases with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Wong JSM, Tan GHC, Chia CSC, Ong J, et al.

    World J Surg Onco 2020

    JIF: 1.966, times cited: NA
  • High grade complication associated with poor overall survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Tan JWS*, Tan GHC*, Ng WY, Ong C-AJ, et al.
    
Int J Clin Oncol 2020

    JIF: 2.503, times cited: 1 (* Equal contribution)
  • Dual-selective magnetic analysis of extracellular vesicle glycans. Wang Z, Sun X, Natalia, A, Tang CSL, Ang CBT, Ong C-AJ, et al.
    
Matter 2020
    JIF: NA, times cited: 4

Research Trials

  • Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with Oxaliplatin in Patients with Peritoneal Carcinomatosis (PIPAC) (NCT03172416) (Ongoing, Study role: Co-I)
  • PIPAC for Peritoneal Metastases (NCT04956068) (Ongoing, Study role: Co-I)
  • Radical resection and HIPEC for recurrent retroperitoneal sarcoma (NCT03792867) (Ongoing, Study role: PI)
  • Prophylactic HIPEC for colorectal cancers at high risk of developing peritoneal metastases (NCT03422432) (Ongoing, Study role: Co-I)