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Adj Asst Prof Leow Leong Chai

Adj Asst Prof Leow Leong Chai


Senior Consultant

Singapore General Hospital

Specialty: Respiratory and Critical Care Medicine

Clinical Interest: Sleep Medicine, Chronic Non-invasive Ventilation

Conditions Treated by this Doctor:
Intensive Care Medicine, Narcolepsy​, Pleural Diseases, Pulmonary Infections, Sleep Disorders.

Clinical Appointments

  • Head & Senior Consultant SingHealth Duke-NUS Sleep Centre
  • Director Sleep Disorders Singapore General HospitalSingapore General Hospital
  • Senior Consultant Respiratory & Critical Care Medicine Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Adj Asst Professor, Singhealth Duke NUS
  • Clinical Senior Lecturer, NUS-YLL School of Medicine


​Asst Prof Leow graduated with degree in medicine from the University of Calgary in Canada before completing postgraduate specialist training in Sleep and Respiratory Medicine in New Zealand. He moved to Singapore in September 2013 and started work as a Consultant at the Department of Respiratory and Critical Care Medicine as well as the Sleep Disorders Unit here at Singapore General Hospital (SGH).

Apart from his work in Respiratory Medicine, he has a special interest in Sleep medicine and Chronic Non-Invasive Ventilation (NIV), and runs the Chronic NIV service in SGH, the largest such service in Singapore.  He manages patients with a wide range of respiratory conditions such as chronic cough, asthma, COPD and bronchiectasis, and sleep disorders ranging from obstructive sleep apnoea, circadian rhythm disorders to narcolepsy and chronic respiratory failure.

He is the current service chief for the SingHealth Duke-NUS Sleep Centre in SGH. He has published research on Vitamin D and respiratory tract infections as well as cardiac biomarkers in obstructive sleep apnoea. He is currently involved in research on CPAP interfaces and the use of AutoPAP in selected CPAP populations.


  • ​2011 Fellow, Royal Australasian College of Physicians (FRACP) [Respiratory and Sleep Medicine     

  • 2002 Doctor of Medicine (MD), University of Calgary, Canada 

Professional Appointments and Committee Memberships

  • Chairman, Sleep Chapter, Academy of Medicine Singapore

  • Clinical Assistant Professor, ​Duke-NUS Medical School

  • Service Chief, SingHealth Duke-NUS Sleep Centre            

  • Executive Committee, Singapore Sleep Society 2016                            

  • Member, American Academy of Sleep Medicine 2013 

  • Member, Thoracic Society of Australia & New Zealand 2008


  • ​Residency in SingHealth Excels (RiSE) Outstanding Faculty Award 2017

  • Singapore Health Quality Service Award (Star) 2017

  • Singapore Health Quality Service Award (Gold) 2016

  • Service with A Heart Award 2015

Research Interests


  1. Leow LC, S. Siti Raudha. Sleep onset latency on overnight PSG is complementary to epworth sleepiness score for predicting shorter mean MSLT sleep latency and OSA severity. Sleep Medicine. 2017 Dec; 40(S1) Pe188.
  2. Lee CHK, Leow LC, Song PR, Li HH, Ong TH. Acceptance and Adherence to Continuous Positive Airway Pressure Therapy in patients with Obstructive Sleep Apnea (OSA) in a Southeast Asian privately funded healthcare system. Sleep Sci. 2017 Apr-Jun; 10(2): 57–63.
  3. Sok Yuen Beh , Leong Chai Leow. Fungating breast cancer and other malignant wounds: epidemiology, assessment and management.. Expert Review of Quality of Life in Cancer Care. March 7 2016.
  4. Leow LC, Baskaran L, Tan SY Tan, Ong TH. Impact of different hypopnea definitions on predictive accuracy of apnea hypopnea index for coronary artery calcification. European Respiratory Journal Sep 2014, 44 (Suppl 58) DOI:
  5. Soh R, Leow L, Toh S, Ong TH. Selection Of CPAP Interface: A Pilot Study To Compare Initial Sleep Technologists' Recommendation Of Interface With Patients' Preferred Choice After A Trial Of The Interfaces. Chest. 2015;148(4_MeetingAbstracts):1060A. doi:10.1378/chest.2271869.
  6. R. Siti Nur Zakiah, S. Siti Raudha, T.H. Ong, L.C. Leow. Clinical and polysomnographic determinants of sleepiness in a South East Asian Population. World Sleep Congress, Prague 2015.
  7. YX Tay, TH Ong, L Leow, SR Senin, PR Song. Characteristics of REM-related Obstructive Sleep Apnea in a Southeast Asian Cohort. Sleep Down Under Oral presentation, Sydney 2014.
  8. Leow L, Campbell A, Neil A. Highly Sensitive Cardiac Troponin Levels Correlate With Obstructive Sleep Apnoea Severity But Remain Elevated After Six Weeks CPAP Treatment. SLEEP DISORDERED BREATHING AND CARDIOVASCULAR DISEASE: OF RODENTS AND HUMANS : pp. A3866-A3866 doi:10.1164/ajrccm-conference.2012.185.1_MeetingAbstracts.A3866
  9. Leow L, Simson T, Cursons R, Karalus N, Hancox R. Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia. Respirology.  2011 Jan 18. doi: 10.1111/j.1440-1843.2011.01924.x.

Research Trials