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Dr Guo Chang Ming

Dr Guo Chang Ming

​MBBS, M Med (Surg), FRCS (Ortho) (Edin), FAMS

Senior Consultant

Singapore General Hospital

Specialty: Orthopaedic Surgery

Sub-specialties: Spine Service

Conditions Treated by this Doctor:
Cervical Disc Arthroplasty, Kyphoplasty, Minimally Invasive Spine Surgery, Scoliosis Surgery.

Clinical Appointments

  • Senior Consultant Orthopaedic Surgery Singapore General HospitalSingapore General Hospital


Dr Guo graduated from National University of Singapore. He subsequently specialised in Orthopaedic Surgery and did his fellowship in spinal surgery. His subspecialty interests include minimally invasive spinal surgery, scoliosis surgery, kyphoplasty and cervical disc arthroplasty. He currently practises at Singapore General Hospital and Gleneagles Hospital. He is also a visiting spine consultant at Kadang Kerbau Women and Children’s Hospital and at the Singapore School Health Service Scoliosis Clinic.
Besides clinical work, Dr Guo has a passion for teaching and research. He currently teaches at the Duke – NUS Graduate Medical School and the National University of Singapore. He is an invited speaker at several regional conferences and hospitals. He has organized many spine specialty courses. He was awarded the National Medical Research Council – STPB award to do research at Harvard Medical School. His basic research interests include tissue engineering with human mesenchymal stem cells and fabrication of injectable bone cements with chitin based biomaterials. 


Professional Appointments and Committee Memberships

  • Fellow of Academy of Medicine (FAMS) - 1 May 2005
  • Joint Speciality Fellowship Examination in Orthopaedic Surgery FRCS (Orthopaedics) - 28 Nov 2004
  • Master of Medicine (Surgery) National University of Singapore - 31 July 2000
  • The Royal College of Surgeons (Edinburgh) MRCS (Member of the Royal College of Surgeons) - 3 Sept 1999
  • United States Medical Licensing Examination (USMLE) Educational Commission for  Foreign Medical Graduates (ECFMG Certification) - 15 May 1998  
  • The Royal College of Surgeons of Edinburgh MMED (Surg) / AFRCS - 23 Dec 1997


Research Interests



  • Parental Body Mass Index: A predictor of childhood obesity. Published in the Annals Academy of Medicine, 1993; 22,3 Pg 342  - 347 
  • Congenital Isolated upper limb hypertrophy with hand abnormality. Published in the Journal of Hand Surgery ,Oct 2001, Vol 26B(5),      Pg 492 - 495 
  • Chapter on tissue engineering of tendons and ligaments. Published in book entitled Scaffolds in Tissue Engineering by Marcel Dekker (2005) 
  • HSV-1 amplicon viral vector mediated gene transfer to human bone marrow derived mesenchymal stem cells. Published in Cancer Gene Therapy June 6, 2008, doi:10.1038 

Research Trials

  • Flt 3 Ligand expanded bone marrow mesenchymal stem cells for cartilage tissue engineering. Singhealth Grant (2006 and 2007) 
  • Development of automated Kerrison Punch with NTU. Working prototype developed. Notice of invention filed. 
  • Characterization of Human Bone Marrow-Derived Mesenchymal Stem Cells Before and after Viral vectors infection. Collaboration with NCC. 
  • Development of novel injectable biomaterial for the bone. Collaboration with NUS, department of Chemistry. Current status of filing for patent (Patent Pending). PhD project completed.