Measles Virus IgM, Measles Virus IgG, Measles Virus Total Ab
Measles IgM or IgG Antibody Measles Total Antibody
3 – 5 mL plain blood. (a) To diagnose acute measles infection, send single acute sample for measles IgM and a second serum taken two weeks later for measles total antibody. (b) To diagnose past infection or for evidence of immunity, send single sample for measles IgG.
Refrigerate samples if delay in transporting to laboratory is anticipated. Do not freeze.
Measles IgM : Enzyme Immunoassay (EIA) Measles IgG : Enzyme Immunoassay (EIA) Measles total Ab : Complement Fixation Test (CFT)
Acute infection : Acute serum positive for IgM. A negative IgM result within 5 days of onset of illness should be repeated +/- send convalescent sample for total Ab (a ≥ 4x rise in titre will confirm acute infection). Past infection/Immunity : Presence of IgG in the absence of specific IgM
Measles IgM : <1 – 4 days Measles IgG : <1 – 7 days Measles Total Ab : 1 – 6 days
Measles IgM : Tuesday and Friday
Measles IgG : Thursday
Measles Total Ab : Tuesday and Thursday