Skip Ribbon Commands
Skip to main content
Menu

KRAS/BRAF MUTATION ANALYSIS

Synonym(s):

Description

Indications

​This assay detects 18 mutations in codons 12, 13, 61, 117 and 146 of the KRAS gene and V600E in exon 15 of the BRAF gene. The presence of these mutations correlates with a lack of response to certain EGFR inhibitor cancer therapies in metastatic colorectal cancer patients.

Specimen Required

​Paraffin embedded tissue block sent to the Histopathology Section.
Alternatively, unstained slides can be sent to the Histopathology Section.
Note :
- At least 8 sections of 8 mm thickness, or 12 sections of 5 mm thickness for smaller biopsies should be sent together with one H&E slide, 4 mm thick with a coverslip as a reference slide.
- Tumour content must be indicated and must be at least 30%.

Storage and Transport

Method

​EntroGen KRAS/BRAF Mutation Analysis Kit (v1.2), using allele-specific real-time PCR.

Test Results

​Detected, Not Detected or Inconclusive

Reference Interval / Value

Turnaround Time

​10 days   

Day(s) Test Set up

​Variable

Remarks

Change History Notes

Others

TOP

What's New

Sort by :