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INTERPHASE FLUORESENCE IN SITU HYBRIDIZATION PANEL TEST FOR MULTIPLE MYELOMA HYPERDIPLOIDY

Synonym(s):

​MM HYPERDIPLOIDY FISH PANEL

Description

Indications

​FISH DNA probes: CEP 9, CEP 11 and CEP 15 are used in the detection of hyperdiploidy in multiple myeloma (MM). A positive hyperdiploid result indicates a favourable outcome.

Specimen Required

​Bone marrow in sodium/lithium heparin.

Storage and Transport

Method

​Fluorescence In Situ Hybridization using direct-labelled FISH DNA probes are hybridized to target loci and analysed under fluorescence microscopy. The probes include: CEP 9, CEP 11 and CEP 15.

Test Results

​Positive or Negative for the FISH panel. FISH findings are reported in accordance to the International System for Human Cytogenomic Nomenclature (ISCN, 2016).

Reference Interval / Value

Turnaround Time

​3 ~ 10 days

Day(s) Test Set up

​Monday – Saturday (office hours)

Remarks

​The FISH Panel test is charged as a separate test from any accompanying cytogenetic test.

Change History Notes

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