Skip Ribbon Commands
Skip to main content
Menu

HEPATITIS B VIRUS (HBV) DRUG RESISTANCE TESTING (YMDD)

Synonym(s):

​      YMDD testing

Description

Indications

​To detect mutations or polymorphisms at codons 80, 173, 180, 181, 184, 194, 202, 204, 236 and 250 of the HBV polymerase gene. Mutations at these positions may confer resistance of HBV to antiviral drugs such as lamivudine, telbivudine, emtricitabine, adefovir, tenofovir and entecavir.

Specimen Required

​5 mL blood in sterile EDTA container or 2 mL plasma (separated from EDTA-treated or whole blood) in sterile screw-capped polypropylene tube. Samples should be collected from patients positive for HBV DNA with a viral load of >10,000 copies/mL or >2,000 IU/mL.

Storage and Transport

​Refrigerate sample until transfer to laboratory. Do not freeze. Send sample at 2 - 8°C (with an ice-pack). Sample must reach the laboratory within 24 hours after collection.

Method

​Reverse hybridization line probe assay using INNO-LiPA HBV Multi-DR (Fujirebio Europe).

Test Results

​Wild, Mutant or Coexistence of Wild and Mutant type detected. The mutation will be described.

Reference Interval / Value

Turnaround Time

​2 - 15 days

Day(s) Test Set up

​Variable

Remarks

Change History Notes

Others

TOP

What's New

Sort by :