C-KIT (Exons 9 & 11)
Screening of GIST tumor samples for mutations in the KIT gene may be helpful in the diagnosis, prognostication and management of patients with GIST. This assay detects mutations found in exon 9 and 11 of KIT gene, from formalin-fixed paraffin-embedded GIST samples.
Paraffin embedded tissue block sent to the Histopathology Section.
Alternatively, unstained slides can be sent to the Histopathology Section. At least 8 sections of 8 micrometers thickness, or 12 sections of 5 micrometers thickness for smaller biopsies should be sent together with one H&E slide, 4 micrometers thick with a coverslip as a reference slide. Tumour content must be indicated and must be at least 30%.
Polymerase Chain Reaction followed by direct Sanger sequencing (in-house test)
Detected, Not Detected or Inconclusive
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