Synonym(s):
Varicella Zoster IgG, VZV IgG Ab, VZV IgG, VZV IgG Rapid (Call Lab First), VZV IgM, VZV IgM Ab, Varicella Zoster IgM, VZV Total Antibody, VZV CF Antibody
VZV IgM Antibody (anti-VZV IgM) VZV IgG Antibody (anti-VZV IgG) VZV Total CF Antibody (anti-VZV total) VZV IgG Antibody (anti-VZV IgG Rapid)
3 – 5 mL plain blood. (a) To diagnose acute varicella infection, send single acute sample for VZV IgM antibody and a second serum taken two weeks later for VZV total CF antibody on the pair. (b) To diagnose past infection and immunity, send single sample for VZV IgG antibody. (c) For urgent screening for immunity, send sample for VZV IgG antibody (Rapid).
Refrigerate samples if delay in transporting to laboratory is anticipated. Do not freeze.
Anti-VZV IgM: Immunofluorescence assay Anti-VZV IgG: Enzyme Immunoassay Anti-VZV total: Complement Fixation Test Anti-VZV IgG (Rapid): Enzyme linked fluorescence assay (for urgent testing)
Acute infection: Single sample positive for VZV IgM Ab and/or paired sera showing ≥ 4 fold rise in total CF Ab titres.Immunity: VZV IgG Ab present. Where antibody levels are low, this will be indicated on the report.
Urgent cases: Anti-VZV IgM : 3 – 4 hrs Anti-VZV IgG (Rapid): 1 – 48 hrs Routine cases: Anti-VZV IgM: <1 – 4 days Anti-VZV IgG: <1 – 7 days Anti-VZV total: 1 – 6 days after acute or second sample
Anti-VZV IgM/IgG (Rapid) : Stat for urgent cases
Anti-VZV IgM : Tuesday and Friday
Anti-VZV IgG : Tuesday
Anti-VZV total : Tuesday and Thursday
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