Synonym(s):
Varicella Zoster IgG, VZV IgG, VZV IgG Rapid (Call Lab First), VZV IgM, Varicella Zoster IgM, VZV Total Antibody
VZV IgM VZV IgG VZV Total Antibody VZV IgG (Rapid)
3 – 5 mL plain blood. (a) To diagnose acute varicella infection, send single acute sample for VZV IgM and a second serum taken two weeks later for VZV total antibody. (b) To diagnose past infection or immunity, send single sample for VZV IgG. (c) For urgent screening for immunity after exposure, send sample for VZV IgG (Rapid).
Refrigerate samples if delay in transporting to laboratory is anticipated. Do not freeze.
VZV IgM : Immunofluorescence assay (IFA)VZV IgG : Enzyme Immunoassay (EIA)VZV total Ab : Complement Fixation Test (CFT)VZV IgG (Rapid) (for urgent testing only) : Enzyme linked fluorescence assay (ELFA)
Acute infection: Single sample positive for VZV IgM and/or paired sera showing ≥ 4 fold rise in total Ab titres.Immunity: VZV IgG present
Urgent cases: VZV IgM : 3 – 4 hrs VZV IgG (Rapid) : 1 – 48 hrs Routine cases: VZV IgM : <1 – 4 days VZV IgG : <1 – 7 days VZV total Ab : 1 – 6 days
VZV IgM/IgG (Rapid) : Stat for urgent cases
VZV IgM : Tuesday and Friday
VZV IgG : Thursday
VZV total Ab : Tuesday and Thursday
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