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Drug Class: Commonly Known As: Category:
Multi-Kinase Inhibitor Lenvima® Cancer-related

Lenvatinib - Side Effects, Precautions, and Contraindications

What side effects can Lenvatinib cause?

  • Increased blood pressure
    • Monitor your blood pressure regularly and record it down. Inform your doctor if you notice an increasing trend.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired
  • Diarrhea
    • Drink plenty of clear fluids to replace those lost (two litres everyday)
  • Decreased appetite, nausea or vomiting
    • Take small, frequent meals throughout the day
  • Mouth sores or ulcers
    • Rinse your mouth after every meal using an alcohol-free mouthwash or salt water
    • Brush your teeth with a soft toothbrush
  • Voice hoarseness
  • Stomach discomfort
  • Weight loss
  • Joint or muscle ache, headache
    • You may take paracetamol when necessary to help with this
  • Palms of the hands or soles of the feet may become numb, sore, red or dr
    • Moisturize these areas daily
    • Avoid wearing tight-fitting shoes

 If you experience any of the following symptoms, you should stop your medication and see your healthcare professional immediately.

  • Abnormal heartbeat, chest pain or shortness of breath
  • Very bad swelling of hands, feet or lower legs
  • Dark urine or light coloured stools
  • Yellowing of your eyes or skin
  • Very bad diarrhea, nausea, vomiting or stomach pain
  • Pain while urinating
  • Abnormal muscle cramps or numbness
  • Unusual weakness, tiredness or lightheadedness
  • Unusual bleeding, bruising, black sticky stools or blood in urine
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

Before taking Lenvatinib, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You or your partners becomes pregnant or is planning for pregnancy
    • You should use effective birth control during and for at least one month after stopping treatment.
  • You are breastfeeding
    • Do not breastfeed during and for at least two weeks after stopping treatment
  • You are taking any other medications, including supplements, traditional medications, and herbal remedies
  • You have any other medical conditions (e.g. heart problems, high blood pressure)
  • You have any recent or upcoming surgery

What food or medicine must I avoid when I take Lenvatinib?

​Avoid medications that are known to interfere with heart rhythms.

Lenvatinib - Additional Information

  • Updated on Monday, August 31, 2020
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

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