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Colchicine - Dosage and How to Use

How should Colchicine be used?

Colchicine comes in 500mcg tablets.

Colchicine should be taken as prescribed by the doctor. It is usually given orally after food. The tablets should be swallowed whole, with a glass of water.

Colchicine may be given in two ways.

  • Your doctor may prescribe a smaller dose such as 500mcg once or twice daily regularly for a period of months to years to prevent flare, or a higher dose such as 500mcg three times daily for a few days to relieve a flare that is occurring.
  • Your doctor may reduce the dose if you have kidney or liver problems, or take medicines that interact (interfere) with Colchicine.

You may start to see improvement within a few hours especially if it is started at the first sign of a flare, but it may take up to several weeks to experience its full benefit when you are using it regularly for gout prevention or Behcet's disease. When used for prevention purpose, your doctor may decide to stop Colchicine when you have no symptoms for a few months.

What should I do if I miss a dose?

If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the dose you missed. Resume the next dose at regular timining. Do not double the dose to make up for the missed dose

What should I do if I overdose?

  • Updated on Friday, June 12, 2015
  • Article contributed by Department of Pharmacy, Rheumatology & Immunology Singapore General Hospital

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