Patients require nasoendoscopic examination and diagnosis are confirmed when a biopsy performed showed histological evidence of NPC. Post-nasal space biopsy is usually performed under topical local anaesthesia and nasoendocopic guidance in the outpatient setting.
The procedure is often uncomplicated and takes less than 10 minutes. For patients on anti-coagulants or anti-platelets, their medication may be stopped prior to the procedure to prevent excessive bleeding.
Blood investigations such as serum EBV VCA-IgA (viral capsid antigen), EBV Ea-IgA (early antigen) and EBV DNA have been used as a method for screening for NPC but routine screening of the general population who is not at increased risk is not advised.