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Assoc Prof Hwang Ying Khee William

Senior Consultant/Medical Director, NCCS

Department of Division of Medical Oncology

MBBS, M Med (Int Med), MRCP (UK), FAMS, FRCP (London)

Associate Professor William Hwang Ying Khee was appointed Medical Director, National Cancer Centre Singapore (NCCS) on 26 November 2017.

A highly respected clinician leader with a strong leadership and professional track record, Associate Professor Hwang has provided stewardship for his multiple leadership portfolios, including Director, SingHealth Transplant; Head, SingHealth Duke-NUS Blood Cancer Centre; Head, Department of Haematology, Singapore General Hospital and Medical Director, Singapore Cord Blood Bank (SCBB).

Widely recognised for his expertise in haematological malignancies, Associate Professor Hwang was formerly President of the World Marrow Donor Association. He is currently the Advisory Committee Member for the Center for International Blood & Marrow Transplant Research (CIBMTR), Executive Board Member of the Asia Pacific Blood and Marrow Transplantation Group (APBMT) and the Chairman of the Chapter of Haematologists, Singapore.

An established researcher who has garnered over $4 million in research funding, Associate Professor Hwang is also a faculty member of the Cancer and Stem Cell Biology Programme in Duke-NUS where he runs a research lab. He has also published close to a hundred clinical and scientific papers in the field of haematology and oncology as well as two books and several book chapters.

In his new role as Medical Director, NCCS, Associate Professor Hwang will further advance NCCS into a global leading cancer centre, and improve patient care through clinical services, education and research.

PROFESSIONAL APPOINTMENTS & COMMITTEE MEMBERSHIPS

• Executive Board Member, Asia Pacific Blood and Marrow Transplant Group (since 2014)
• Advisory Committee Member, Centre for International Blood and Marrow Transplant Research (CIBMTR), since 2015
• President, World Marrow Donor Association (WMDA) 2013-2015
• President, Singapore Society of Haematology (SSH) 2012-2014
• Program Director, Haematopoietic Stem Cell Transplant Program, SGH 2007-2013
• Director, SingHealth Transplant 2015 - 2017
• Associate Professor, Hematopoietic Stem Cell Laboratory, Cancer and Stem Cell Biology Program, Duke-NUS Medical School since 2007
• Past President Singapore Society of Haematology, 2013-2015
• Co-Chair, SingHealth Duke-NUS Congress 2012
• Scientific Co-Chairperson, Annual Scientific Meeting Singapore General Hospital 2011
• Clinical Lecturer, Yong Loo Lin School of Medicine, NUS
• Visiting Consultant, Health Sciences Authority
• S(P)EAR committee member, World Marrow Donor Association since 2011
• Previous Chair (2008-2010), Divison of Medicine Research Workgroup, Singapore General Hospital
• Society of Transplantation, Singapore (Committee member 1997-2000, Treasurer 2001-2005, committee member 2005-2008)
• Singapore Society of Haematology (Treasurer 2002-2004), Committee Member (present)
• Secretary (2010), Chapter of Hematologists, Singapore
• American Society for Blood and Marrow Transplantation (member), 2006 - present
• American Society of Hematology (member), 2004 – present
• Editorial Board, BMC Hematology
• Journal Reviewer: Biology of Blood and Marrow Transplantation, Cytotherapy, Transplantation Immunology, Journal of Hematology and Oncology, World Journal of Pediatrics, Annals of Academy of Medicine and Singapore Medical Journal
• Content Expert, Immunodeficiency and Immunosuppression, Body and Disease Course, Duke-NUS Medical School since 2015
• Content Expert, Blood and Immunity, Normal Body Course, Duke-NUS Medical School since 2015

AWARDS

     • SingHealth Game Changer Award 2017
• SingHealth GCEO Excellence Awards: Outstanding Clinician Researcher Award 2015
• SingHealth Transplant Most Outstanding Doctor Award 2015
• Duke-NUS Pioneer Award 2013
• Outstanding Faculty for Engagement (Molecules and Cells) 2012
• Singapore Health Quality Service Award (Star) 2011
• Graduate Diploma in Healthcare Management and Leadership (Singapore Management University) 2010
• Heart of Gold Award (SGH) 2010
• Distinguished Faculty, Molecules and Cells, Duke-NUS Medical School.  2010
• Singapore General Hospital Service Quality “Service with a Heart” Award #5; February 2009
• EXSA Excellent Service Award (Gold), 2008
• Singapore General Hospital Service Quality “Service with a Heart” Award #3 and 4; 2007 (x2)
• Outstanding Faculty, Body and Disease Course.  Duke-NUS Medical School.  2008
• EXSA Excellent Service Award (Silver) 2007
• SingHealth Mentorship grant award for attachment to Fred Hutchinson Cancer Research Center 2006
• SingHealth Long Service Award 2005
• SMJ Best Reviewers Award 2005
• Singapore General Hospital Best Oral Paper (Medicine) 2004
• Singapore General Hospital Service Quality “Service with a Heart” Award #2; February 2003
• Singapore General Hospital Essay Competition 2002—Best Essay “Reinventing SGH for the future”
• HMDP fellowship in Haematology and Bone Marrow Transplantation 2000 to 2001
• Singapore General Hospital Service Quality “Service with a Heart” Award; January 2000

PUBLICATIONS AND RESEARCH/TRIALS

  Publications  

     1. Yeates L, Slatter MA, Bonanomi S, Lim FLWI, Ong SY, Dalissier A, Barberi W, Shulz A, Duval M, Heilmann C, Willekens A, Hwang WHY, Uderzo C, Bader P, Gennery AR. Use of defibrotide to treat transplant-associated thrombotic microangiopathy: a retrospective study of the Paediatric Diseases and Inborn Errors Working Parties of the European Society of Blood and Marrow Transplantation. Bone marrow transplantation. 2017; 52(5):762-764.
2. Chan TS, Lee YS, Del Giudice I, Marinelli M, Ilari C, Cafforio L, Guarini A, Tan D, Phipps C, Goh YT, Hwang W, Goh AZ, Siu LL, Wu S, Ha CY, Lin SY, Kwok CH, Lau CK, Wong KF, Foà R, Kwong YL, Tse E. Clinicopathological features and outcome of chronic lymphocytic leukaemia in Chinese patients. Oncotarget. 2017; 8(15):25455-25468.
3. Wang L, Allen J, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Lim F, Oon L, Tan TT, Linn YC, Tan BH. Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: Predictive value of the immunodeficiency scoring index. Transplant infectious disease : an official journal of the Transplantation Society. 2017;
4. Zhou W, Sultana R, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Koh LP, Koh M, Loh Y, Tan P, Linn YC. Long term renal outcome after allogeneic haemopoietic stem cell transplant: A comprehensive analysis of risk factors in an Asian patient population. Clinical transplantation. 2017; 31(4). PubMed [journal]PMID: 28135776
5. Maka VV, Koh LP, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Koh M, Lim F, Lim ZY, Loh Y, Poon M, Del Rosario DR, Tai BC, Tan LK, Tan P, Linn YC . An exploration of the applicability of the refined disease risk index and its integration with other independent risk factors for individualized prognostication. Bone Marrow Transplant. 2016 Oct 31.
6. Phipps C, Ho AY, Linn YC, Gopalakrishnan S, Ang AL, Lee JJ, Ng HY, Lim FW, Goh PS, Loh YS, Tan PH, Koh LP, Koh MB, Lee LH, Goh YT, Ong YW, Hwang WY. Thirty Years of Bone Marrow Transplantation in the Singapore General Hospital. Ann Acad Med Singapore. 2016 Jul;45(7):315-7
7. Thien SY, Chung SJ, Tan AL, Hwang WY, Tan BH, Tan TT. Recurrent trichosporonosis with central nervous system involvement in an allogeneic hematopoietic stem cell transplant recipient. Transpl Infect Dis. 2016 Oct;18(5):768-772
8. Tan CW, Tan-Koi WC, Ng J, Chan CM, Hwang WY. A cluster of Epoetin-associated pure red cell aplasia: clinical features and the possible association of HLA-DRB1*12:02. Pharmacogenomics. 2016 Jul;17(11):1235-1243.
9. Liu CC, Ma DL, Yan TD, Fan X, Poon Z, Poon LF, Goh SA, Rozen SG, Hwang WY, Tergaonkar V, Tan P, Ghosh S, Virshup DM, Goh EL, Li S. Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy. Stem Cells. 2016 Oct;34(10):2471-2484.
10. Szer J, Elmoazzen H, Fechter M, Hwang W, Korhonen M, Miller J, Mengling T, Shaw B, Stein J. Safety of Living Donation of Hematopoietic Stem Cells. Transplantation. 2016 Jun;100(6):1329-31.
11. Ghosh A, Tan TT, Linn YC, Gopalakrishnan S, Goh YT, Hwang W, Tan BH, Ho A, Phipps C. What We Learned From Plasma BK-Virus Monitoring in Allogeneic Hematopoietic Transplant Recipients. Transplantation. 2016 Apr;100(4):e17-8.
12. Sorensen BS, Szer J, Shaw B, Korhonen M, Mengling T, Fechter M, Elmoazzen H, Lindberg B, Chapman J, Nørgaard JM, Foeken L, Hwang WY, Nielsen B. Inadvertent completely HLA-mismatched allogeneic unrelated bone marrow transplant: lessons learned. Bone Marrow Transplant. 2016 Mar 14.
13. Ong SY, de Mel S, Chen YX, Ooi MG, Surendran S, Lin A, Koh LP, Linn YC, Ho AY, Hwang WY, Phipps C, Loh SM, Goh YT, Tan D, Chng WJ, Gopalakrishnan SK. Early relapse post autologous transplant is a stronger predictor of survival compared with pretreatment patient factors in the novel agent era: analysis of the Singapore Multiple Myeloma Working Group. Bone Marrow Transplant. 2016 Mar 14.
14. Tang T, Chen Z, Praditsuktavorn P, Khoo LP, Ruan J, Lim ST, Tan D, Phipps C, Lee YS, Goh YT, Hwang W, Tao M, Quek R, Farid M, Furman RR, Leonard JP, Martin P. Role of Surveillance Imaging in Patients With Peripheral T-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2016 Mar;16(3):117-21.
15. Bari S, Chu PP, Lim A, Fan X, Bunte RM, Li S, Ghosh S, Chiu GN, Hwang WY. Mitochondrial superoxide reduction & cytokine secretion skewing by carbon nanotube scaffolds enhance ex vivo expansion of human cord blood hematopoietic progenitors. Nanomedicine. 2015 Jun 24. pii: S1549-9634(15)00134-3.

Other Publications
1. Krishnan S, Hwang WY. The clinical applications of hematopoietic stem cells. Asia Pacific Biotech News 2011
2. Reinventing SGH for the future. SGH Proceedings 2002
3. Sun L, Tan P, Hwang W, Aw SE. An In Vitro Study Of Specific Differentiation And Functional Characterisation Of Human Cord Blood Derived Megakaryocytes. SGH Proceedings. 11 (3): 190-195.

Book Chapters
1. Hwang W, Tan P, Hematological Disorders in the Elderly (chapter), in Medicine and Surgery for the Older Person.
2. Hwang W, Teoh G. Immunotherapy in Haematology (chapter), in A Clinical Approach to Medicine (2nd Ed).
3. Embracing Hope: Chronicles of Blood Stem Cell transplants. (Book published by SingHealth Academy)
4. Ong SY, Hwang W. Banking of Cord Blood.  Umbilical Cord Stem Cells: A Future for Regenerative Medicine (published by World Scientific Publishing).
5. Chowdhury, Ong, Balakrishnan and Hwang W. Umbilical cord blood stem cells: collection, storage and uses, in Stem Cells: From Bench to Bedside, 2nd Edition (published by World Scientific Publishing)

Last Modified Date :04 Jan 2010