Symposium 3

Dr Xie Wanying
Senior Consultant, Department of Nuclear Med & Molecular Imaging
Singapore General Hospital

Dr Xie Wanying is a senior consultant nuclear medicine physician with the Department of Nuclear Medicine and Molecular Imaging. She is the program director in the nuclear medicine senior residency program.

She obtained her fellowship of the Royal College of Radiologists in 2011. She received a HMDP fellowship award for PET- MRI and PET- CT to University College London and Royal Marsden Hospital, United Kingdom.

Her interest is in PET-MRI and the application of PET-MRI in oncology and neurology.

Session:

Content & Creativity, 7 October 2022, 1415 - 1615 hrs
Imaging Active Fibrosis in Interstitial Lung disease

Systemic sclerosis (SSc) associated interstitial lung disease (ILD) is a leading cause of mortality in SSc. The complex interplay of immune dysregulation and activated fibroblasts are key mediators in SSc. High-resolution CT (HRCT), pulmonary function test (PFT) and clinical indices do not always correlate with disease progression. Profibrotic processes could account for suboptimal responses to current immunomodulatory-based treatments, particularly in patients with a predominant fibrotic phenotype.

Positron emission tomography (PET) tracer, 68Ga-FAPI, has high specificity for fibroblast activation protein alpha (FAP), a marker of activated fibroblasts. This has been used to image IgG4-related disease and idiopathic pulmonary fibrosis.

We investigate 68Ga-FAPI-46 PET/computed tomography (CT) as a non-invasive imaging tool to assess fibrotic activity in SSc-ILD.

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