Research Activities

Head and Neck Surgery

• Surgery and adjuvant radiotherapy versus concurrent chemo-radiotherapy for resectable stage III and IV head and neck squamous cell carcinoma. NMRC grant obtained.
• Photodynamic therapy in management of Nasopharyngeal carcinoma.
• Genetic Studies in Head and Neck Cancer - the association of the H19 gene with nasopharyngeal cancer.
• Nasopharyngeal carcinoma: Radiotherapy versus concurrent chemo-radiation therapy in treatment for advanced staged disease.
• Nasopharyngeal carcinoma: Study early detection and development of a vaccine.

Otology

• Effect of radiation on the ear.
  Investigate radiation-induced apoptosis in inner ear hair-cells and middle ear effusion.
• Cochlear Implantation in Children and Adults.
  Investigate factors contributing to the success of cochlear implantation.
• Childhood Hearing Screening and Intervention.
  Investigate universal newborn hearing screening and the results of early intervention.
• Racial differences in the practice of Otology.
  Study the impact of racial anatomical and physiological differences on the practice of Otology.
• Genetic aspects of childhood hearing loss.
  Study pheynotypic and genotypic correlations of hereditary non-syndromic hearing loss in Singapore.

Laryngology and Voice

• Efficacy of percutaneous hyaluronic-acid injection to improve voice and swallowing in patients with unilateral vocal-fold paralysis.
• Anatomy of the South East Asian larynx related to vocal fold medialisation procedures to treat unilateral vocal fold paralysis.
• Near infrared atuofluorescence and Raman spectroscopy for head and neck diagnosis.
• Role of electrical stinulation (e-stim) in treating swallowing disorders. Multi-centre trial.
• Lateralisation of motor cortex excitability in vocalisation and muscial tasks.
• Effectiveness of gatric acid suppression therapy in treatment of laryngeal pathology.
• Prevalence of voice disorders in occupational voice users in Singapore.
• Laryngeal electromyography in patients with vocal fold paralysis following head and neck radiotherapy.

Rhinology

• Role of endoscopic ligation of sphenopalatine artery in the management of epistaxis.
• Endoscopic sinusotomy in the management of frontal sinus disease.
• Multimedia Book on Endoscopic Sinus Surgery.
• Nasal Obstruction and Smell. Study effect of nasal obstruction on Eustachian tube dysfunction, snoring and headaches. Development of a new olfactometer.z
• Three-dimensional CT angiography (3DCTA) of the internal carotid artery for preoperative evaluation of sinonasal lesions and intraoperative surgical navigation: to assess the role of 3DCTA, when combined with intraoperative surgical navigation, in the applications of minimally invasive endoscopic approaches to the skull base.
• Evaluation of skull base lesions with CT and MR image fusion for preoperative planning and intraoperative endoscopic surgical navigation: to assess the role of CT-MRI image fusion studies for diagnostic evaluation and/or preoperative planning during intraoperative endoscopic surgical navigation.

Snoring & Obstructive Sleep Apnea

• The effects of radiofrequency treatment of the palate on snoring : a prospective study.
• The effects of radiofrequency treatment of the nasal turbinates on nasal congestion.
• Morphological assessment of snorers and non-snores : a comparative study.

Paediatric Otolaryngology

• Analysis of more than one thousand skin prick allergen tests in children.
• Endoscopic Transnasal correction of Choanal Atresia.