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RESEARCH ACTIVITIES


1. Head and Neck Surgery

  • Surgery and adjuvant radiotherapy versus concurrent chemo-radiotherapy for resectable stage III and IV head and neck squamous cell carcinoma. NMRC grant obtained.

  • Photodynamic therapy in management of Nasopharyngeal carcinoma.

  • Genetic Studies in Head and Neck Cancer - the association of the H19 gene with nasopharyngeal cancer.

  • Nasopharyngeal carcinoma: Radiotherapy versus concurrent chemo-radiation therapy in treatment for advanced staged disease.

  • Nasopharyngeal carcinoma: Study early detection and development of a vaccine.


2. Otology

  • Effect of radiation on the ear.
    Investigate radiation-induced apoptosis in inner ear hair-cells and middle ear effusion. 

  • Cochlear Implantation in Children and Adults.
    Investigate factors contributing to the success of cochlear implantation.

  • Childhood Hearing Screening and Intervention.
    Investigate universal newborn hearing screening and the results of early intervention.

  • Racial differences in the practice of Otology.
    Study the impact of racial anatomical and physiological differences on the practice of Otology.

  • Genetic aspects of childhood hearing loss.
    Study pheynotypic and genotypic correlations of hereditary non-syndromic hearing loss in Singapore.  

3. Laryngology and Voice

  • Efficacy of percutaneous hyaluronic-acid injection to improve voice and swallowing in patients with unilateral vocal-fold paralysis.

  • Anatomy of the South East Asian larynx related to vocal fold medialisation procedures to treat unilateral vocal fold paralysis.

  • Near infrared atuofluorescence and Raman spectroscopy for head and neck diagnosis.

  • Role of electrical stinulation (e-stim) in treating swallowing disorders. Multi-centre trial.

  • Lateralisation of motor cortex excitability in vocalisation and muscial tasks.

  • Effectiveness of gatric acid suppression therapy in treatment of laryngeal pathology.

  • Prevalence of voice disorders in occupational voice users in Singapore.

  • Laryngeal electromyography in patients with vocal fold paralysis following head and neck radiotherapy.


4. Rhinology

  • Role of endoscopic ligation of sphenopalatine artery in the management of epistaxis.

  • Endoscopic sinusotomy in the management of frontal sinus disease.

  • Multimedia Book on Endoscopic Sinus Surgery.

  • Nasal Obstruction and Smell. Study effect of nasal obstruction on Eustachian tube dysfunction, snoring and headaches. Development of a new olfactometer.z

  • Three-dimensional CT angiography (3DCTA) of the internal carotid artery for preoperative evaluation of sinonasal lesions and intraoperative surgical navigation: to assess the role of 3DCTA, when combined with intraoperative surgical navigation, in the applications of minimally invasive endoscopic approaches to the skull base.

  • Evaluation of skull base lesions with CT and MR image fusion for preoperative planning and intraoperative endoscopic surgical navigation: to assess the role of CT-MRI image fusion studies for diagnostic evaluation and/or preoperative planning during intraoperative endoscopic surgical navigation.

5. Snoring & Obstructive Sleep Apnea

  • The effects of radiofrequency treatment of the palate on snoring : a prospective study.

  • The effects of radiofrequency treatment of the nasal turbinates on nasal congestion.

  • Morphological assessment of snorers and non-snores : a comparative study.

6. Paediatric Otolaryngology

  • Analysis of more than one thousand skin prick allergen tests in children.

  • Endoscopic Transnasal correction of Choanal Atresia.